منابع مشابه
Symmetry scheme for amino acid codons.
Group theoretical concepts are invoked in a specific model to explain how only twenty amino acids occur in nature out of a possible sixty four. The methods we use enable us to justify the occurrence of the recently discovered 21st amino acid selenocysteine, and also enables us to predict the possible existence of two more, as yet undiscovered amino acids.
متن کاملGC-Content of Synonymous Codons Profoundly Influences Amino Acid Usage
Amino acids typically are encoded by multiple synonymous codons that are not used with the same frequency. Codon usage bias has drawn considerable attention, and several explanations have been offered, including variation in GC-content between species. Focusing on a simple parameter-combined GC proportion of all the synonymous codons for a particular amino acid, termed GCsyn-we try to deepen ou...
متن کاملCombinatorics, Homology and Symmetry of codons
In nuclear physics and elementary particle theory concept of unitary symmetry and the related idea of the hierarchy of interactions play a fundamental role [1, 2]. So the relative smallness of the electromagnetic and weak interactions as compared to the strong interaction of the nucleons in the nucleus can be considered a model of the nucleus in the limit of exact symmetry of the strong interac...
متن کاملForced Ambiguity of the Leucine Codons for Multiple-Site-Specific Incorporation of a Noncanonical Amino Acid
Multiple-site-specific incorporation of a noncanonical amino acid into a recombinant protein would be a very useful technique to generate multiple chemical handles for bioconjugation and multivalent binding sites for the enhanced interaction. Previously combination of a mutant yeast phenylalanyl-tRNA synthetase variant and the yeast phenylalanyl-tRNA containing the AAA anticodon was used to inc...
متن کاملExploiting unassigned codons in Micrococcus luteus for tRNA-based amino acid mutagenesis.
An alternative to suppression of stop codons for the biosynthetic insertion of non-natural amino acids has been developed. Micrococcus luteus , a Gram-positive bacterium, is incapable of translating at least two codons. One of these unused codons was inserted in a gene to act as a nonsense site. An aminoacylated tRNA was synthesized which was complementary to this codon. The gene containing the...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2002
ISSN: 1063-651X,1095-3787
DOI: 10.1103/physreve.65.021912